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BOTOX® vs. DAXXIFY™: Similarities and Differences


BOTOX is a household name that has remained the gold standard as the anti-aging injectable for decades. However, a new challenger has recently arrived on the market: DAXXIFY, an FDA-approved BOTOX alternative that lasts twice as long.

At VITAHL, we stay on top of the latest innovations in skin care. As a leader in the medical aesthetic world, it is important that we inform our patients of the newest products and technological advancements so you can decide which is right for you. We’re excited to be one of the first medical aesthetic practices to offer DAXXIFY and we can’t wait to share more about this groundbreaking treatment.

Meet DAXXIFY: The New BOTOX Killer? 

DAXXIFY is a neurotoxin in the same product category as BOTOX, Dysport, and Xeomin. Each of these injectables are similar in that they “freeze” facial muscles to smooth away wrinkles, but DAXXIFY is shaking things up with its staying power. Compared to BOTOX and other competitors that wear off after about three months, DAXXIFY is the first in its class to last for six months or longer. In clinical trials, some patients showed DAXXIFY lasting up to nine months. This means fewer touch-ups to maintain a youthful appearance. 

With all the buzz and excitement around DAXXIFY, one of the first innovations to hit the neurotoxin market in over 30 years, it has already been dubbed “the BOTOX killer” by industry experts. While it’s ultimately up to you on which product you prefer, we’re pleased to give patients the option to access this high-quality, longer-lasting treatment option. 

Ingredients Comparison

If DAXXIFY is also made from botulinum toxin and works similarly to BOTOX, what is the secret behind its longer-acting duration? DAXXIFY is the first and only injectable neurotoxin to be stabilized with Peptide Exchange Technology™ (PXT), which helps enhance its performance as a wrinkle-smoother. Thanks to these proprietary peptides, DAXXIFY is also free of both human serum albumin and animal-based components found in other popular neurotoxins, including BOTOX, Dysport and Xeomin. Although these ingredients are purified and pose no risk, some patients may prefer a product without them.

How Does DAXXIFY Work?

Much like other neurotoxins, DAXXIFY works by restricting muscle activity in the treated areas. More specifically, it temporarily blocks the release of acetylcholine, an important neurotransmitter that acts as a messenger between nerve cells. When these signals are blocked, the muscles stay relaxed thus reducing the appearance of fine lines and wrinkles that appear when you smile, frown or laugh. 

Although all neurotoxins are formulated differently, they work in a similar way to smooth away unwanted lines and wrinkles. However, key differences in ingredients, composition, dosage, viscosity and more can translate into unique effects. For example, some brands, like Dysport, tend to feather more easily once injected to provide more natural-looking results where DAXXIFY’s proprietary peptides help it last almost twice as long.

BOTOX vs. DAXXIFY: Benefits


  • Leader in non-surgical anti-aging treatments that has been trusted for decades
  • FDA-approved with a long history of safety and efficacy
  • Softens the appearance of wrinkles for up to three months
  • Can be used to treat frown lines, forehead lines, crow’s feet, and much more
  • Prevents new lines from developing and softens current lines in treated areas
  • Medical and aesthetic applications
  • More suitable for first time neurotoxin users
  • Quick, simple, and easy non-invasive procedure 


  • Newest innovation in the neurotoxin market
  • FDA-approved and backed by clinical trials
  • Softens the appearance of wrinkles for six to nine months
  • Indicated for frown lines but studies show it may also effectively treat other areas
  • Prevents new lines from developing in treated areas
  • No human or animal-derived components
  • More suitable for experienced neurotoxin users
  • Non-invasive treatments can be completed in under 15 minutes

What Can DAXXIFY Treat?

DAXXIFY is used to temporarily reduce the appearance of moderate-to-severe frown lines. It can reduce the signs of aging between the eyes by limiting activity in the underlying muscles. However, clinical studies show that it may also be effective in treating wrinkles in other areas of the face, such as forehead, eyes, and mouth. For now, DAXXIFY has only received FDA-approved for cosmetic concerns, but doctors expect that it will be used off-label for other concerns such as excessive sweating, migraine and more.

Ideal Candidates for BOTOX vs. DAXXIFY

The long-lasting effects of DAXXIFY may make it more appealing for “BOTOX veterans” compared to those who are new to anti-aging injectables. That’s because experienced users will be familiar with the type of results they want or expect from treatment. Once neurotoxins like BOTOX or DAXXIFY are injected, the effects cannot be reversed if the outcome isn’t something you’re happy with. That’s why it is important to choose an experienced provider who is an expert in facial anatomy and thoroughly understands your unique goals. 

So Which One is Right for Me?

Both BOTOX and DAXXIFY can produce excellent results by smoothing away unwanted facial lines and wrinkles. Which one is best for you will depend on your individual needs, goals and preferences. If you’re looking for something longer lasting, our team may recommend DAXXIFY, while others might prefer the results they receive from BOTOX or Dysport. During your consultation, our experienced medically licensed clinicians can help you review the pros and cons of each neurotoxin to help you decide.

Schedule a Consultation at VITAHL

DAXXIFY is the newest FDA-approved neurotoxin on the market that’s making waves due to its unique formulation and long-lasting results. If you’d like to learn more and find out if this treatment is right for you, schedule a consultation with us today. You can book your appointment by clicking here or calling our office in Denver, Colorado, at 303-388-7380.